Every Cure

Every Cure is a nonprofit on a mission to save and improve lives by repurposing existing medicines. Our core research program is the MATRIX (ML/AI-enabled Therapeutic Repurposing In eXtended uses) platform — an AI-powered, open-source engine that systematically evaluates all FDA-approved drugs against all known diseases to surface the highest-impact repurposing opportunities.

What is MATRIX?

MATRIX pioneers a field we call computational pharmacophenomics: a drug-agnostic, disease-agnostic approach that scores ~75 million drug–disease pairs using biomedical knowledge graphs, machine learning models, and real-world evidence. The platform integrates a human-in-the-loop medical review process, where our clinical team evaluates top-ranked predictions for biological plausibility, strategic fit, and clinical viability.

Datasets on HuggingFace

Our current datasets include our

• Drug List: The Drugs against which we predict
• Disease List: The Disease list against which we predict
• KG Nodes & Edges: Our intermediate data artifact. We combine multiple upstream KGs and data sources to build an integrated KG. For a high level overview of the data, check our data dashboard
• MATRIX predictions: A dataset that contains a recent version of our predicted scores. A global heatmap application allows top down exploration of these scores.

Code & Documentation

Publications

• Lancet Haematology (2025) — Pioneering a new field of computational pharmacophenomics to unlock the life-saving potential of existing medicines. Fajgenbaum DC et al. everycure.org/lancet
• Platform paper (preprint, 2025) — Every Cure's End-to-End AI-Enabled Drug Repurposing Platform: Integrating Human-in-the-Loop Expertise to Accelerate Impact. DOI: 10.58647/REXPO.25000098.v1
• MeDI (under submission) — MeDI: A Foundational Database to Support Drug Repurposing — covers the MATRIX drug and disease list creation process.

Program

• Active repurposing programs portfolio
• ARPA-H Phase 1 announcement
• ARPA-H award page

Disclaimer

The scores and predictions shared by Every Cure are the output of a computational research pipeline and are intended for research purposes only. They do not constitute medical advice, clinical recommendations, or endorsement of any drug for any use. Every Cure makes no warranties, express or implied, regarding the accuracy, completeness, or fitness for any particular purpose of the information presented. Drug repurposing opportunities identified here require rigorous independent scientific and clinical validation before any clinical application.